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Issue 01
Ling Jiang1, Yan Tan2, JieTian1, Hong-Yu Ma2, Jin-Tao Li3*, Chao-Zhi Luo1*
Ibrain 2015;1(1):1-8 Download
Abstract
Backround: Stroke-associated pneumonia (SAP) is the most common complication after stroke, which increases the long-term mortality. In the acute phase of brain ischemia, obvious pathological injury is observed, which act as a main inducer for SAP. In this study, we sought to investigate the pathological changes following brain ischemia at each pulmonary lobe. Methods: Transient middle cerebral artery occlusion (tMCAO) was applied as a model of cerebral ischemia/reperfusion (I/R) injury (CIRI). Zea-Longa neurological deficit score was assessed at 24h post-injury and TTC staining was used to confirm the successful establishment of model. Histology and lung water content of each pulmonary lobe were conducted to evaluated the degree of lung injury. Results: Anatomy revealed that pulmonary lobes were divided into five single lobes. The posterior lobe of right lung gained the lowest histopathologic score while the highest water content was observed in left single lobe. Conclusions: Therefore, different pulmonary lobes may differ in the degree of lung injury induced by brain ischemia. This provide a novel and rigorous method for the study of lung injury.
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